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Articles by Yohei Kono
Nuclear Wrinkles Result From Geometric Adaptations to Cellular and Nuclear Morphological Changes in Epithelial Cells
1 Introduction Mechanical stress from the extracellular and cellular microenvironments can regulate cell fate, behavior, and tissue homeostasis. As the largest and stiffest organelle, the nucleus that houses the genome acts as a major mechanical element within the cell (Kaminski et al. 2014; Maurer and Lammerding 2019).
Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells
Abstract The assessment of nuclear structural changes is considered a potential biomarker of metastatic cancer. However, accurately measuring nuclear elasticity remains challenging. Traditionally, nuclear elasticity has been measured by indenting the cell membrane with a bead-attached atomic force microscopy (AFM) probe or aspirating isolated nuclei with a micropipette tip.
Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome
Abstract The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lamins contribute to the protection against NE rupture induced by mechanical stress. Lamin A (LA) and a short form of the splicing variant lamin C (LC) are diffused from the nucleoplasm to sites of NE rupture in immortalized mouse embryonic fibroblasts (MEFs).
Modeling framework for batch‐dependent dynamics of reaction process by combining first principles and machine learning
REFERENCES 1, . Practice and challenges of chemical process control engineers: what they achieved in the past and should attack in the future. Syst Control Inform. 2008; 52(8): 262-269. (in Japanese). 2. Pipeless process and its application for FACIM in chemical industry. J Jpn Petrol Inst. 1993; 36(2): 65-72. (in Japanese). 3, , . Process Control Engineering. Asakura Publ; 2020. (in Japanese). 4, . Model predictive control-I (basic principles): history & present status. Syst Control Inform.
Comprehensive analysis of A-type lamin tail region for repairing the nuclear lamina
Abstract The nuclear lamina (NL) lines the inner nuclear membrane (INM) of the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lamins contribute to the protection against NE rupture induced by mechanical stress. Lamin C (LC) but not lamin A (LA) is rapidly diffused from the nucleoplasm to sites of NE rupture induced by laser microirradiation in immortalized mouse embryonic fibroblasts (MEFs).
Modulation vector of the Fulde-Ferrell-Larkin-Ovchinnikov state in ${\mathrm{CeCoIn}}_{5}$ revealed by high-resolution magnetostriction measurements
Abstract The Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) state is an exotic superconducting phase formed by Cooper pairs with finite center-of-mass momentum q. On theoretical grounds, the superconducting order parameter in the FFLO state is spatially modulated along the q vector, and the emergence of an associated anisotropy is expected at the phase transition from the Abrikosov state to the FFLO state.
Anomalous electromagnetic response in the spin-triplet superconductor ${\mathrm{UTe}}_{2}$
Abstract The recently discovered heavy-fermion superconductor UTe2, as a promising candidate for an odd-parity superconductivity, exhibits anomalous magnetic-field reinforced superconductivity with a huge upper critical field of 35 T. However, the thermodynamic properties of this unconventional superconductivity still remain unclear. Herein we present the results of dc magnetization and heat capacity measurements in UTe2 to probe the magnetic response at low temperatures.
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