Yola Moride

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Introduction Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy (TMA), primarily caused by a deficiency in the von Willebrand factor (VWF)-cleaving enzyme ADAMTS13 (A disintegrin and metalloproteinase with thrombospondin motifs 13).1–3 This deficiency can be the result of mutations in the ADAMTS13 gene (hereditary/congenital TTP; cTTP) or, more commonly, result from ADAMTS13 autoantibodies (acquired/immune TTP; iTTP).3 An ADAMTS13 activity of...