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Diabetes mellitus is associated with morbid complications such as diabetic foot ulcers (DFUs) that may lead to amputations or mortality if not managed adequately. New adjunctive interventions to treat diabetic wounds include topical biologics and growth factors. This study aims to evaluate their efficacy in improving wound-healing outcomes and safety. Comprehensive database searches of MEDLINE via PubMed, EMBASE, and Cochrane were performed from inception to December 2022.
At baseline, 39,564 individuals were identified for eligibility screening. The final sample of 36,556 (92.3%) individuals with T2D was included in the present analysis. The flowchart detailing the study design is shown in Fig. 1. During mean follow-up of 6 years, 2492 (6.8%) individuals died from all causes, of which 690 (27.7%) deaths were due to CVD.
Diabetes self-management and education (DSME) is an integral part of diabetes care and has been shown to improve glycemic control, reduce complications, and increase quality of life (1). The traditional model in which clinicians and diabetes educators share responsibility for patient education faces challenges such as reduced access to care during the pandemic and a shortage of trained educators.
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