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Yongying Zhou on Muck Rack

Yongying Zhou

As seen in: Nature, MDPI
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Articles

MMP7-Triggered mitophagy by regulating parkin-mediated ubiquitination of VDAC1 confers anoikis resistance in the epithelium of hyperplastic prostate

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By Yongying Zhou, Huan Liu, Junchao Zhang, Lu Du, Huan Lai, Ping Chen, Yuming Guo, Yongwen Luo, Michael DiSanto, Xinhua Zhang, Jizhang Qiu
| Nature Verified
Abstract Benign prostatic hyperplasia (BPH), prevalently in aging men, is characterized by aberrant cell death of prostate cells. Anoikis, a specific subtype of apoptosis, is triggered when cells detach from the extracellular matrix (ECM), in contrast, cells with anoikis resistance contribute to pathological processes such as unregulated cell proliferation and impaired cell death. However, the role of anoikis resistance in BPH pathogenesis remains poorly understood.
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Simvastatin Improves Benign Prostatic Hyperplasia: Role of Peroxisome-Proliferator-Activated Receptor-γ and Classic WNT/β-Catenin Pathway

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By Zhen Kun Wang, Shu Yang, Daoquan Liu, Yongying Zhou
| MDPI
3. Discussion Our novel data show that PPARγ is localized in the epithelial and stromal compartments of human prostate tissue and is downregulated in hyperplastic prostate tissue. We also demonstrate that SV ameliorates the progression of BPH both in vivo and in vitro through apoptosis, cell cycle arrest at the G0/G1 phase, attenuation of tissue fibrosis, and the EMT process via upregulating PPARγ and inhibiting the WNT/β-catenin pathway.
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