Yoshiya Katahira on Muck Rack

Yoshiya Katahira

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Optimization of galectin-3 binding agents by in situ multiple compound synthesis and native mass spectrometry - Scientific Reports

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By Kazuki HOSHI, Tsuyoshi Konuma, Satoko Akashi, Akira Katsuyama, Satoshi ICHIKAWA, Rina Taguchi, Yoshiya Katahira
| Nature Verified
Abstract Developing high-affinity drug lead critically depends on the efficient structural optimization of a lead compound. However, the dynamic nature of the process by which drugs bind to target molecules often complicates the rational design of effective substituents, even if their three-dimensional structure is available. Herein, we report a streamlined strategy for the optimization of a galectin-3 binder through the integration of in situ chemistry and native mass spectrometry.
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