Youn Young Lee

1 Introduction Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases associated with the progressive loss of synapses in the cerebral cortex and hippocampus, resulting in cognitive decline (DeKosky and Scheff, 1990). The pathological hallmarks of AD include extracellular accumulation of amyloid-beta (Aβ) protein and abnormally processed intraneuronal tau protein, also known as neurofibrillary tangles (NFTs) (Armstrong, 2009).

4. Discussion In this retrospective study, 71.7% of patients experienced hypotensive events during femur fracture surgery. The patients in the IOH group had a lower PMA normalized by BSA than those in the no-IOH group, both in male and female patients. The present study demonstrated that preoperative PMA measured by CT showed an excellent AUC value for predicting IOH in older adult patients undergoing femur fracture surgery.