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Youna Vandaele on Muck Rack

Youna Vandaele

As seen in: Nature, Wiley Online Library
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Articles

Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes

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By Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley S. Province, Nathalie Thiriet, Patricia H. Janak, Youna Vandaele
| Nature Verified
Abstract Mesolimbic dopamine (DA) neurons are central to cue-guided reward seeking and action sequence learning. Yet, the mechanisms by which cue-induced DA neural activity drives goal-directed or habitual sequence execution remain unknown. We designed two novel tasks to isolate the effect of sequence-delineating cues on DA-driven behavioral strategies and learning. In the lever insertion fixed-ratio 5 task (LI5), the lever insertion marked sequence initiation.
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Delay of punishment highlights differential vulnerability to developing addiction-like behavior toward sweet food - Translational Psychiatry

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By Marcello Solinas, Jean-Emmanuel Longueville, Youna Vandaele
| Nature Verified
Abstract Resistance to punishment is commonly used to measure the difficulty in refraining from rewarding activities when negative consequences ensue, which is a hallmark of addictive behavior. We recently developed a progressive shock strength (PSS) procedure in which individual rats can titrate the amount of punishment that they are willing to tolerate to obtain food rewards. Here, we investigated the effects of a range of delays (0–12 s) on resistance to punishment measured by PSS break points.
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Large‐scale brain correlates of sweet versus cocaine reward in rats

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By Magalie Lenoir, Université de Bordeaux, Sylvia Navailles, Youna Vandaele
| Wiley Online Library Verified
Abstract Cocaine induces many supranormal changes in neuronal activity in the brain, notably in learning- and reward-related regions, in comparison to nondrug rewards - a difference that is thought to contribute to its relatively high addictive potential.
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