Young‐Hee Shin on Muck Rack

Young‐Hee Shin

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Articles

Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling

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By Young‐Hee Shin, Hana Cho, Jonghoon Kim, Jaeyoung Ha
| Color Research & Application Verified
Cover Picture PDF ShareShare Abstract Neurodegenerative diseases are characterized by the accumulation of misfolded proteins such as tau protein. In their Research Article (DOI: 10.1002/anie.202013915), Seung Bum Park et al. perform a cell‐based phenotypic screening and identify a small molecule, SB1617, capable of suppressing abnormal assembly of tau protein under the ER stress.
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Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling

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By Hana Cho, Jonghoon Kim, Jaeyoung Ha, Young‐Hee Shin
| Color Research & Application Verified
Abstract Tau protein aggregates are a recognized neuropathological feature in Alzheimer's disease as well as many other neurodegenerative disorders, known as tauopathies. The development of tau‐targeting therapies is therefore extremely important but efficient strategies or protein targets are still unclear.
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