Younis Hazari

Abstract IRE1α (inositol-requiring enzyme type 1) is one of the primary sensor arms of UPR signalling pathway with special ability to detect unfolded/misfolded proteins in the ER lumen. It is a bifunctional protein with kinase and endoribonuclease activity, playing a crucial role in managing ER stress. The C-terminal domain of IRE1α, facing towards the cytosol, acts as a scaffold for various effector proteins to regulate IRE1α activity.

New Results doi: https://doi.org/10.1101/2023.05.02.538835 Abstract Collagen is one the most abundant proteins and the main cargo of the secretory pathway, contributing to hepatic fibrosis and cirrhosis due to excessive deposition of extracellular matrix. Here we investigated the possible contribution of the unfolded protein response, the main adaptive pathway that monitors and adjusts the protein production capacity at the endoplasmic reticulum, to collagen biogenesis and liver disease.