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Differential Expression of Human and Bacterial Proteins Re- 2 veals Microbiome-Host Crosstalk in Metabolic Disorders

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By Fabiano Thompson, Cristiane Thompson, Youssef Bacila Sade
| preprints.org
Submitted: 22 January 2026 You are already at the latest version The rising global prevalence of obesity and related disorders, including metabolic syn-drome (MetS) and type 2 diabetes (T2DM), highlights the need to better understand the mechanisms underlying these conditions, particularly host–microbiota interactions. While the gut microbiota has been extensively studied, the role of the oral microbiota and its interaction with human salivary proteins remains poorly explored.
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