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Youssef Fouani on Muck Rack

Youssef Fouani

As seen in: BioRxiv
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Articles

STARR-CRAAVT: A platform to design cell type-specific regulatory elements for next-generation gene therapy

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By Robert Becker, Priyanka Roy Choudhury, Martin Oti, Youssef Fouani
| BioRxiv
Abstract Precise control of transgene expression through novel enhancer-promoter combinations is a promising strategy for advancing gene therapy mediated by adeno-associated virus (AAV). We present STARR-CRAAVT, a novel STARR-Seq-derived platform to screen for enhancers in the AAV context. Using HepG2 and HaCaT cells as screening models, we applied STARR-CRAAVT for the identification of cell type-specific enhancers.
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