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Articles

Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging

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By Xumeng Wu, Yu Jia Tan, Hui Ting Toh, Lan Huong Nguyen
| Royal Society of Chemistry Verified
Targeted bioimaging or chemotherapeutic drug delivery to achieve the desired therapeutic effects while minimizing side effects has attracted considerable research attention and remains a clinical challenge. Presented herein is a multi-component delivery system based on carbohydrate-functionalized gold nanoparticles conjugated with a fluorophore or prodrug. The system leverages active targeting based on carbohydrate–lectin interactions and release of the payload by biological thiols.
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