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Yu Leying

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Articles

Causal Relationships Between the Gut Microbiota, Inflammatory Cytokines, and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Analysis

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By Ma Caiyun, Wen Hebao, Li Changqing, Yu Leying
| Wiley Online Library Verified
1 Introduction Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disease of obscure etiology that fundamentally affects motor neurons (MNS) in the motor cortex and spinal cord (Pribac et al. 2024). Like most neurodegenerative diseases, ALS usually starts with local muscle weakness and progresses to most muscles, including the diaphragm, and ultimately the patient dies of respiratory paralysis within 3–5 years (Alonso et al. 2009).
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