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Yuanguangyan Zhang on Muck Rack

Yuanguangyan Zhang

As seen in: Nature
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Articles

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity

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By Abhinav Illendula, Charles K. Hewett, Yuki Hayata, Lauren S. Strathearn, Nicola de Prisco, Aasthika Das, David Rossell, Michael Slifker, Beicheng Sun, Joan Font-Burgada, Guoshun He, Laia Carballo-Botinas, Sara Navas-Sanz, Maria Niqui-Capdevila, Avril Garcia-Santos, Rocío Bernabé-Pérez, Alejandra Bustillo-Bustos, Ani Mikoyan, Eleanor Helm, Marina Gonzalez-Sorribes, Yuanguangyan Zhang, Naiara Akizu
| Nature Verified
Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma but are widely considered weak or cooperative drivers, raising the question of how their oncogenic potential is contextually regulated. Aging and chronic injury are major determinants of cancer risk.
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