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Yuanyin Li on Muck Rack

Yuanyin Li

As seen in: Frontiers
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Acupuncture modulates extracellular vesicle-miRNA-HMOX1 axis to inhibit ferroptosis in polycystic ovary syndrome: integrating machine learning, in vitro and in vivo studies

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By Xiaoling Wu, Shumin Guo, Huiling Chen Verified, Tingyu Chen, Liansha Huang, Hai Zhou, Yuanyin Li, Naxin Wang
| Frontiers
Abstract Background: Acupuncture therapy shows promise for polycystic ovary syndrome (PCOS), but its molecular mechanisms remain unclear. This study investigates whether acupuncture alleviates PCOS by regulating granulosa cell (GC) ferroptosis via extracellular vesicles (EVs). Methods: Bioinformatic analysis of KGN cell transcriptome data identified heme oxygenase-1 (HMOX1) as a key candidate. Its role was validated in a PCOS rat model and GCs using RT-qPCR, western blot, and immunohistochemistry.
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