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Yuanying Feng

As seen in: Cell Reports Medicine
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Articles

Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy

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By Yuan Gao Verified, Yuchao He, Chengmeng Wang, Ran Zuo, Yi Luo, Wei Liu, Ping Yue, Wenchen Gong, Yu Wang, Liwei Chen, zhiyong Liu, Peng R. Chen, Hua Guo, Xiangdong Tian, Duo Zuo, Yuanying Feng, Aomei Ling
| Cell Reports Medicine Verified
Keywords non-small cell lung cancer trilaciclib neutrophils senescence cGAS-STING pathway immune checkpoint blockade Introduction Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related mortality.1,2 Although immunotherapy improves survival in advanced NSCLC, the overall objective response rate to single-agent immune checkpoint inhibitors remains less than 20%.3,4,5,6 Based on these considerations, the combination of immunotherapy with...
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