Yuanzhang Jin on Muck Rack

Yuanzhang Jin

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Articles

Methylmalonic Acid, an Aging‐Associated Metabolite, Accelerates Intervertebral Disc Degeneration by Inducing Disc Vascularization via the CCL7/JAK2‐STAT3/VEGF Signaling Axis

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By Runtian Zhou, Xiaonan Wang, Yuanzhang Jin
| Wiley Online Library Verified
1 Introduction Intervertebral disc (IVD) degeneration (IVDD) is the primary cause of low back pain and restricted lumbar mobility (Oscar et al. 2018; Wen et al. 2023). It is currently the most prevalent spinal degenerative disorder, imposing a substantial economic burden on society (Chen et al. 2024; Xia et al. 2024). A hallmark feature of IVDD is metabolic imbalance, characterized by decreased anabolism and increased catabolism of the extracellular matrix (ECM).
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