Yudibeth Sixto-López

Introduction Click to copy section linkSection link copied! Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder characterized by the excessive hepatic production of oxalate, which is formed from glyoxylate when its normal metabolic conversion to glycine is impaired (Figure 1A). (1,2) Oxalate accumulation leads to recurrent nephrolithiasis, nephrocalcinosis, and progressive renal failure, often culminating in systemic oxalosis.

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Abstract Valproic acid (VPA) is a compound currently used in clinical practice for the treatment of epilepsy as well as bipolar and mood disorders. VPA targets histone deacetylases (HDACs), which participate in the removal of acetyl groups from lysine in several proteins, regulating a wide variety of functions within the organism. An imbalance or malfunction of these enzymes is associated with the development and progression of several diseases, such as cancer and neurodegenerative diseases.