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Yuejiang Jiao

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Reversal of canonical Wnt/β-catenin signaling pathway attenuates gestational diabetes mellitus-induced offspring cardiac hypertrophy: mechanistic insights into pathological remodeling

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By Xun Yuan, Zexin Huang, Yiling Chen, Ducai Liu, Zexin Zhao, Qiulian Zhu, Yuan Qin, Guiping Zhang, Caixian Yang, Ning Hou, Yuejiang Jiao, Ruchao Jiang, Zhimei Feng
| Nature Verified
Abstract Gestational diabetes mellitus (GDM), a prevalent prenatal metabolic disorder characterized by hyperglycemia occurring in approximately 9.2% of pregnancies globally, imposes significant cardiovascular risks on offspring, including developmental cardiac hypertrophy and long-term functional impairment. Despite its clinical importance, the molecular mechanisms governing GDM-induced cardiac malformations remain elusive.
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