Yuen Ting Lam

Graphical Abstract Inert Material Bioactivation Important classes of materials employed in biomedical applications are chemically inert but are resistant to traditional surface modification. In article number 2311313, Miguel Santos, Steven G. Wise, and co-workers describe a new class of plasma polymerised nanoparticles that can uniformly coat a range of synthetic and natural polymers mimicking the outcomes of plasma coating technology but vastly expanding its applicability.

1. Introduction MicroRNAs (miRNAs) are evolutionarily conserved small, non-coding RNAs that post-translationally inhibit or degrade target mRNAs [1]. miRNAs are estimated to regulate the expression of up to 60% of all protein-coding genes [2], making them essential players in various cellular processes, including development, differentiation, proliferation, and apoptosis.

Highlights • Revascularization for PAD has been characterized by the adaptation of technologies from the treatment of CAD, with few therapies specifically developed for PAD. • In light of recent increases in all-cause mortality driven by endovascular PAD interventions that employ elution of antiproliferative agents, this review highlights the unmet need to address underlying local inflammation and proposes an alternative therapeutic approach.