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Yuesong Yin

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Kaempferol Attenuates Spaceflight-Associated Knee Cartilage Degradation by Targeting NOX4-Mediated Mitochondrial Dysfunction (Adv. Sci. 48/2026)

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By Yuesong Yin, Ruiling Xu, Meagan Makarczyk
| Wiley Online Library Verified
How to cite Yin, Y., Xu, R., Makarczyk, M.J., Liu, J.-J., Liu, S., Shi, M.Z., Carlo, R.D., Almeida, M.F., Garris, A., Day, S., Sanchez-Hodge, R., Schisler, J.C., Zilberman, A.H., Allen, N.G., Kubik, A.J., Blaber, E.A., Olali, A.Z., Xie, W., Wallace, D.C., Mason, C.E., Alexander, P.G., Intini, G., Beheshti, A. and Lin, H. (2026), Kaempferol Attenuates Spaceflight-Associated Knee Cartilage Degradation by Targeting NOX4-Mediated Mitochondrial Dysfunction (Adv. Sci. 48/2026). Adv. Sci., 13: e77032.
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Kaempferol Attenuates Spaceflight-Associated Knee Cartilage Degradation by Targeting NOX4-Mediated Mitochondrial Dysfunction

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By Yuesong Yin, Ruiling Xu, Meagan Makarczyk
| Wiley Online Library Verified
1 Introduction Space travel plays a crucial role in advancing human exploration of the universe, particularly using crewed spacecraft for in-depth exploration within the solar system. However, spaceflight also presents a unique environment characterized by microgravity, space radiation, isolation, and hostile/closed conditions, which significantly impact human physiology, including loss of bone density and muscle mass and increased inflammation [1, 2].
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Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

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By Yian Yang, Yuesong Yin, Wei Xu, Jiawei Chen, Yanfeng Zou, Xuan Wang, Zhigang Xiao, Zheng Li, Peiguo Cao
| Nature Verified
Abstract Colorectal cancer (CRC) progression is associated with intestinal barrier dysfunction, yet the molecular mechanisms governing mucin glycosylation remain unclear. This study aims to investigate the regulatory pathway controlling MUC2 expression and O-glycosylation in CRC and assess the therapeutic potential of rosiglitazone in restoring mucosal integrity. In this study, B3GNT6 was identified as a key glycosyltransferase that promotes MUC2 O-glycosylation and protein stability.
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