Yuewan Luo on Muck Rack

Yuewan Luo

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Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

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By Lei Wang, Yufeng Xiao, Jiao Mo, Yuewan Luo
| biorxiv.org
Abstract An effective cancer therapy requires both killing cancer cells and targeting tumor-promoting pathways or cell populations within the tumor microenvironment (TME). We purposely search for molecules that are critical for multiple tumor-promoting cell types and identified nuclear receptor subfamily 4 group A member 1 (NR4A1) as one such molecule. NR4A1 has been shown to promote the aggressiveness of cancer cells and maintain the immune suppressive TME.
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