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Yueying An

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Articles

Multifunctional Nano Immunostimulant: Overcoming Immunosuppressive Microenvironment for Antitumor Immunotherapy

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By Guanhong Guo, Wenda Zhong, Huishuang Zhao, Yueying An
| Wiley Online Library Verified
1 Introduction Anti-tumor immunotherapy, which activates or enhances the immune system to recognize and attack tumor cells, has become one of the pillar tumor therapies, like surgery, radiotherapy, and chemotherapy.[1, 2] Despite significant progress, immunotherapy is still limited by the complexity of the TME and challenges related to immune suppression mechanisms, such as hypoxia, high GSH expression, and immune suppression.[3-6] In the hypoxic TME, the HIF-1α pathway is activated,...
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