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Endothelial cells regulate mesangial cells through the Dll4/Notch3 axis to participate in glomerular injury in lupus nephritis
Abstract Introduction: Increasing evidence suggests that microvascular dysregulation mediates mesangial cell (MC) alteration in the pathogenesis of LN (Lupus nephritis). However, the heterogeneity of endothelial cells (ECs) in LN and their regulatory mechanisms on MCs have not been thoroughly investigated. Objective: To elucidate the regulatory role and mechanism of ECs in the development and progression of LN.
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