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Yueying Shan

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Articles

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

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By Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan
| Wiley Online Library Verified
1 Introduction Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by a dismal 5-year survival rate, largely attributable to therapeutic resistance [1, 2]. While combination chemotherapy with albumin-bound paclitaxel plus gemcitabine (AG) has emerged as the standard first-line regimen, its clinical benefits remain limited due to intrinsic and acquired chemoresistance.
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