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Yujia A. Chan

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Articles

Systematic multi-trait AAV capsid engineering for efficient gene delivery - Nature Communications

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By Albert Chen, Isabelle G. Tobey, Kasper Lage, Fatma-Elzahraa Eid, Yujia A. Chan
| Nature Verified
Abstract Broadening gene therapy applications requires manufacturable vectors that efficiently transduce target cells in humans and preclinical models. Conventional selections of adeno-associated virus (AAV) capsid libraries are inefficient at searching the vast sequence space for the small fraction of vectors possessing multiple traits essential for clinical translation.
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Systematic multi-trait AAV capsid engineering for efficient gene delivery

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By Fatma-Elzahraa Eid, Albert Chen, Ken Chan, qin huang, Qingxia Zheng, Isabelle G. Tobey, Simon Pacouret, Casey Keyes, Megan Powell, Binhui Zhao, Kasper Lage, Yujia A. Chan, Benjamin E. Deverman, Pamela P. Brauer, Jencilin Johnston, Alice F. Tarantal
| Flipboard
16 hours ago "She continued to fight back." The livestream of Alaska's fat bears is unfiltered. It can be brutal. On July 27, one of the largest and most dominant bears of Katmai National Park and Preserve's Brooks River attacked a cub, to the dread of web onlookers. The cub looked seriously injured, appeared to …
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