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Mini-HA (#1) is observed to binds to E-cadherin with a dissociation constant (K D ) similar to that of HA (∼2.7 μM vs . ∼2.3 μM) ( 14 Lee K. Zhong X. Gu S. Kruel A.M. Dorner M.B. Perry K. Rummel A. Dong M. Jin R. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. ), and disrupts the epithelial barrier ( Fig. 1 B) ( 14 Lee K. Zhong X. Gu S. Kruel A.M. Dorner M.B. Perry K. Rummel A. Dong M. Jin R.
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