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Open AccessArticle by Igor E. Kasheverov 1,†, Yulia A. Logashina 1,2,†, Fedor D. Kornilov 1,3,†, Vladislav A. Lushpa 1,3, Ekaterina E. Maleeva 1, Yuliya V. Korolkova 1, Jinpeng Yu 4, Xiaopeng Zhu 4, Dongting Zhangsun 4, Sulan Luo 4, Klara Stensvåg 5, Denis S. Kudryavtsev 1, Konstantin S. Mineev 1,3 and Yaroslav A. Andreev 1,2,* 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, str.
The transient receptor potential ankyrin-repeat 1 (TRPA1) is an important player in pain and inflammatory pathways. It is a promising target for novel drug development for the treatment of a number of pathological states. A novel peptide producing a significant potentiating effect on allyl isothiocyanate- and diclofenac-induced currents of TRPA1 was isolated from the venom of sea anemone Metridium senile.
Author contributions: Y. A. L. and Y. A. A. designed the study and wrote the paper. Y. A. L., S. A. K., K. S., and Y. A. A analyzed and critically evaluated the results. I. V. M. and Y. V. K. performed Ca 2+ imaging experiments with TRPA1-expressing cells. Y. A. L. and I. V. S. performed Ca 2+ imaging experiments on DRG neurons. I. A. D., V. A. P., Y. A. P., and A. N. M. designed and performed the experiments on mice. K. S. and Y. A. A. collected venom from sea anemones. Y. A. L.
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