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Prediction of Solvent Penetration Rate-Limited Release of Drug from Amorphous Solid Dispersion Discs of Various Geometries

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By Shuaiqian Men, James E. Polli, Yuly Chiang Yu
| dx.doi.org
1. Introduction Click to copy section linkSection link copied! Many amorphous solid dispersions (ASDs) have been marketed in the last 20 years. (1,2) ASD intermediate fabrication typically converts a poorly soluble active pharmaceutical ingredient (API) into an amorphous form that is dispersed in a hydrophilic polymer matrix. (3) Between 2012 and 2023, 48 products were approved by the U.S. Food and Drug Administration containing ASDs. (1) ASD intermediates are typically glassy at room temperature.
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