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Yuma Tega

As seen in: MDPI
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Articles

Carrier-Mediated Process of Putrescine Elimination at the Rat Blood–Retinal Barrier

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By Yuma Tega, Yoshiyuki Kubo, Hiroaki Miura, Kairi Ri
| MDPI
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The Structural Characteristics of Compounds Interacting with the Amantadine-Sensitive Drug Transport System at the Inner Blood–Retinal Barrier

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By Yusuke Shinozaki, Yuma Tega, Shin-ichi Akanuma, Ken-ichi Hosoya
| MDPI
Abstract : Blood-to-retina transport across the inner blood–retinal barrier (BRB) is a key determinant of retinal drug concentration and pharmacological effect. Recently, we reported on the amantadine-sensitive drug transport system, which is different from well-characterized transporters, at the inner BRB.
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Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells

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By Tomoko Yamaguchi, Toshiki Kurosawa, Yuma Tega, Kei Higuchi
| American Chemical Society
Brain microvascular endothelial cells derived from human induced pluripotent stem cells (hiPS-BMECs) have been proposed as a new blood–brain barrier model, but their transport function has not been fully clarified. Therefore, in this study, we investigated the gene expression and function of transporters in hiPS-BMECs by means of quantitative reverse transcription-PCR, in vitro transcellular transport studies, and uptake experiments.
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