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Yumo Xie on Muck Rack

Yumo Xie

As seen in: Nature
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Articles

ICIsAtlas reveals a suppressive NK cell niche in pan-cancer immunotherapy profiles

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By Yumo Xie, Jinxin Lin, Haotian Liu, Ying Xiong, Junyi Han, Ziying Huang, Jingrong Weng, Zixiao Wan, Puning Wang, Xiaoxia Liu, Linping Wu, Qian Cai, Yanxin Luo, Xiaolin Wang, Huichuan Yu, Peisi Li, Meijin Huang
| Nature Verified
Abstract Immune checkpoint inhibitors (ICIs) have reshaped the treatment in multiple tumors. However, a substantial proportion of patients exhibit limited responses. The lack of harmonized, large-scale pan-cancer ICI datasets coupled with accessible analysis tools hinders the systematic discovery of response biomarkers and resistance mechanisms.
Open in Who Shared Issue with article?

Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity - Cell Death & Disease

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By Yanxin Luo, Huichuan Yu, Yumo Xie
| Nature Verified
Abstract G-quadruplex (G4) is a noncanonical DNA secondary structure known to induce DNA damage and regulate the expression of immune-related genes. We aim to exploit the G4 folding as a treatment strategy to trigger anti-tumor immune response. In this study, we observe that the abundant genomic G4 in epithelial cells coexists with increased infiltration of CD8+ T cells in colorectal cancer tissue.
Open in Who Shared Issue with article?
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