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Articles by Yuning Shen
Sparse Bayesian Group Factor Model for Feature Interactions in Multiple Count Tables Data
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Dynamics of the epigenetic landscape during development and in response to drought stress in sorghum
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Discovering pathways through ribozyme fitness landscapes using information theoretic quantification of epistasis
New Results doi: https://doi.org/10.1101/2023.05.22.541765 Abstract The identification of catalytic RNAs is typically achieved through primarily experimental means. However, only a small fraction of sequence space can be analyzed even with high-throughput techniques.
Dynamics of the epigenetic landscape during development and in response to drought stress in sorghum
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Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes - Nature Communications
Abstract Systems of catalytic RNAs presumably gave rise to important evolutionary innovations, such as the genetic code. Such systems may exhibit particular tolerance to errors (error minimization) as well as coding specificity. While often assumed to result from natural selection, error minimization may instead be an emergent by-product. In an RNA world, a system of self-aminoacylating ribozymes could enforce the mapping of amino acids to anticodons.
Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds
Abstract Chronic wounds represent a large and growing disease burden. Infection and biofilm formation are two of the leading impediments of wound healing, suggesting an important role for the microbiome of these wounds. Debridement is a common and effective treatment for chronic wounds. We analyzed the bacterial content of the wound surface from 20 outpatients with chronic wounds before and immediately after debridement, as well as healthy skin.
A map of the amine-carboxylic acid coupling system
Abstract Chemical transformations determine the structure of a product, and therefore its properties, which in turn affect complex macroscopic functions such as the metabolic stability of pharmaceuticals or the volatility of perfumes. Therefore, reaction selection can influence the success or failure of a candidate molecule to meet a functional objective. The coupling of an amine with a carboxylic acid to form an amide bond is the most popular chemical reaction used for drug discovery1.
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