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Yunsa Huo on Muck Rack

Yunsa Huo

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Articles

Protein corona guided albumin-binding paclitaxel nanoparticles for treatment of intracranial tumors

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By Peng Yu, Tianye Wang, Shihua Yang, Peng Han, Zifan Li, Yunsa Huo
| Nature Verified
Abstract Albumin-bound paclitaxel (Abraxane) exhibits potent antitumor activity, but its suboptimal pharmacokinetics and the restrictive blood-brain barrier (BBB) greatly limit the broader application of albumin-based paclitaxel formulations in intracranial tumors. In this work, we engineered size-uniform (~ 160 nm) paclitaxel-albumin nanoparticles (Fe3+@SA-PTX) via simple one-step nano-precipitation method guided by a “protein corona intervention” strategy.
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