Yunus Taskesenligil

The Journal of Organic Chemistry Cite this: J. Org. Chem. 2026, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.

Introduction Click to copy section linkSection link copied! Tetrahydroquinolines (THQs) are privileged scaffolds with diverse biological activities and a wide occurrence in natural products and pharmaceuticals. (1) Their derivatives display antiviral, (2) antibacterial, (3) antimalarial, (4) anticancer, (5) and neuroprotective properties, (6) while also finding use in catalysis, (7) materials science, (8) and energy technologies.

Introduction Click to copy section linkSection link copied! The aniline core is a fundamental building block in bioactive molecules and donor–acceptor compounds, widely used in pharmaceuticals, agrochemicals, and materials science. (1) Indoline and 1,2,3,4-tetrahydroquinoline (THQ) are aniline derivatives containing a five- or six-membered nitrogen heterocycle fused to a benzene ring. These structures are commonly found in natural products, pharmaceuticals, and functional materials.