Yuqiong Lv

1 Introduction Colorectal cancer (CRC) is a major cause of global morbidity and mortality, highlighting the urgent need for improved diagnostic and treatment strategies.[1] Metastasis is a pivotal phase in the advancement of tumors, the substantial challenge in tumor treatment, and the leading cause of death in patients with CRC.[2] The tumor microenvironment (TME) plays a critical role in tumor cell proliferation, epithelial-mesenchymal transition (EMT), and peritumoral microenvironment...