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Significance Cells confined in complex environments use a combination of chemical and mechanical cues for robust pathfinding and effective migration. Analysis of directional “decision-making” of Dictyostelium discoideum cells migrating within microchannels harboring asymmetric bifurcations shows that unlike neutrophils and immature dendritic cells Dictyostelium cells use chemical rather than barotactic guidance cues.
Abstract Worldwide, prostate cancer sits only behind lung cancer as the most commonly diagnosed form of the disease in men. Even the best diagnostic standards lack precision, presenting issues with false positives and unneeded surgical intervention for patients. This lack of clear cut early diagnostic tools is a significant problem.
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