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Yusuf Dogus Dogru on Muck Rack

Yusuf Dogus Dogru

As seen in: BioRxiv
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The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset

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By Khyati Girdhar, Audrey I Randall, Yusuf Dogus Dogru, Clarissa Howard
| BioRxiv
Abstract Type 1 Diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. The insulin B-chain 9-23 (insB:9-23) peptide is established as a critical epitope in triggering T1D. In our previous study, we showed that Parabacteroides distasonis, a human gut commensal, contains an insB:9-23 mimic in its hprt protein (residues, 4-18). This mimic (hprt4-18) activates insB:9-23 specific T-cells, and colonization of P.
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