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Articles by Yuting Ke
Factors influencing self-care among older patients with heart failure and spouses in China: a mixed methods study
Abstract Objective: This study aimed to investigate the factors influencing self-care among older patients with heart failure (HF) and their spouses from a dyadic perspective. Methods: An explanatory sequential mixed-methods design was employed. In the quantitative phase, 145 dyads of older HF patients and their spouses were recruited from a tertiary hospital in Zhejiang, China.
MRI-based habitat and peritumoral radiomics for predicting HER2 status in breast cancer: a multicenter study
Abstract MRI-based radiomics has shown potential for differentiating HER2-zero, HER2-low, and HER2-positive breast cancers; however, the added value of integrating intratumor heterogeneity (ITH) and peritumoral habitat features remains unclear. In this retrospective retrospective study, 515 patients from five hospitals were included and divided into training, internal testing, and external validation cohorts. Radiomic features were extracted from intratumor, peritumor, and habitat regions.
Influencing factors of patient delay for decision-making in older patients with acute coronary syndrome: a study based on the Andersen’s Behavioral Model
Abstract Objective: This cross-sectional study aimed to identify factors influencing patient delay in older adults with acute coronary syndrome (ACS) using Andersen’s Behavioral Model at a tertiary hospital in Zhejiang Province, China. Methods: A total of 153 older adults diagnosed with ACS who survived to hospital admission were included from January 2023 to June 2023.
Ibudilast‐Mediated Suppression of Neuronal TLR4 in the Prefrontal Cortex Mitigates Methamphetamine‐Induced Neuroinflammation and Addictive Behaviours
1 Introduction Methamphetamine (METH) is a highly addictive and neurotoxic psychostimulant that presents significant public health challenges due to its widespread abuse and the severe neurological and cognitive deficits it induces. Chronic METH use not only leads to addiction and substantial socioeconomic costs but also contributes to neuroinflammation, oxidative stress and neuronal apoptosis, all of which are key components of its neurotoxicity profile [1].
Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in trappc9-linked brain developmental syndrome
ResearchMetabolismNeuroscience Open Access | 10.1172/jci.insight.181339 JCI Insight. https://doi.org/10.1172/jci.insight.181339. Copyright © 2024, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature - Nature Biomedical Engineering
Abstract Bioluminescent probes are widely used to monitor biomedically relevant processes and cellular targets in living animals. However, the absorption and scattering of visible light by tissue drastically limit the depth and resolution of the detection of luminescence.
Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in syndrome caused by mutated trappc9
Abstract Loss-of-function mutations of the gene encoding the trafficking protein particle complex subunit 9 (trappc9) cause intellectual disability and obesity by unknown mechanisms. Genome-wide analysis links trappc9 to non-alcoholic fatty liver disease (NAFLD). The abrogation of trappc9 in mice has been shown to alter the density of neurons containing dopamine receptor D2 (DRD2) and/or DRD1 in the striatum.
Prominent Nonlinear Optical Absorption in SnS2‐Based Hybrid Inorganic–Organic Superlattice
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202400077-sup-0001-SuppMat.docx5.2 MB Supporting Information References 1, , , , , , , Nat. Photonics 2011, 5, 561. 2, , , , , Nature 2019, 569, 208. 3, , , , Nature 2004, 431, 1081. 4, Nature 2003, 424, 831. 5, , , , , , , Nat. Commun. 2013, 4, 2719. 6, , , , , , , Nat. Commun. 2015, 6, 8513. 7, , , , , , Adv. Mater. 2002, 14, 818. 8, , , J. Opt. Soc. Am. B 2015, 32, 31. 9, , , , , Adv. Mater.
Prominent Nonlinear Optical Absorption in SnS2‐Based Hybrid Inorganic–Organic Superlattice
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202400077-sup-0001-SuppMat.docx5.2 MB Supporting Information References 1, , , , , , , Nat. Photonics 2011, 5, 561. 2, , , , , Nature 2019, 569, 208. 3, , , , Nature 2004, 431, 1081. 4, Nature 2003, 424, 831. 5, , , , , , , Nat. Commun. 2013, 4, 2719. 6, , , , , , , Nat. Commun. 2015, 6, 8513. 7, , , , , , Adv. Mater. 2002, 14, 818. 8, , , J. Opt. Soc. Am. B 2015, 32, 31. 9, , , , , Adv. Mater.
Trappc9 deficiency causes obesity and fatty liver disease by constraining dopamine neurotransmission
Abstract Loss-of-function mutations of the gene encoding the trafficking protein particle complex subunit 9 (trappc9) cause intellectual disability and obesity by unknown mechanisms. Genome-wide analysis links trappc9 to non-alcoholic fatty liver disease (NAFLD). Trappc9-deficient mice gain body weight normally in early developmental periods but become overweight shortly after being weaned.
Frontiers | Functional reprogramming of peripheral blood monocytes by soluble mediators in patients with pancreatic cancer and intraductal papillary mucinous neoplasms
1 Introduction Intraductal papillary mucinous neoplasms (IPMN) are cystic precursors to pancreatic adenocarcinoma (PDAC) that account for 15-20% of PDAC cases (1). These precursor lesions are detectable on radiographic imaging and exist on a spectrum of disease from low grade to high grade to those harboring invasive PDAC (2).
Deep learning-enhanced radiomics for histologic classification and grade stratification of stage IA lung adenocarcinoma: a multicenter study
Guotian Pei1†, Dawei Wang2†, Kunkun Sun3, Yingshun Yang1, Wen Tang2, Yanfeng Sun2, Siyuan Yin2, Qiang Liu1, Shuai Wang1 and Yuqing Huang1* 1Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, China 2Institute of Advanced Research, Infervision Medical Technology Co. Ltd., Beijing, China 3Department of Pathology, Peking University People’s Hospital, Beijing, China Background: Preoperative prediction models for histologic...
The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome
1 Introduction Life, in the form of prokaryotes, first appeared on Earth approximately 3.8 billion years ago, while the earliest eukaryotic single-celled organisms emerged approximately 1.8 billion years ago. Evidence suggests that eukaryotes originated from the fusion and aggregation of prokaryotes into multicellular complexes, initially utilizing the genetic information of prokaryotes.
Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons
Abstract Genetic mutations in the gene encoding transport protein particle complex 9 (trappc9), a subunit of TRAPP that acts as a guanine nucleotide exchange factor for rab proteins, cause intellectual disability with brain structural malformations by elusive mechanisms. Here, we report that trappc9-deficient mice exhibit a broad range of behavioral deficits and postnatal delay in growth of the brain.
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