Yuuka Watahiki on Muck Rack

Yuuka Watahiki

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Enhancement of exon skipping activity by reduction in secondary structure content of LNA-based splice-switching oligonucleotides

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By Takenori Shimo, Keisuke Tachibana, Yuki Kawawaki, Yuuka Watahiki
| Royal Society of Chemistry
Enhancement of exon skipping activity by reduction in secondary structure content of LNA-based splice-switching oligonucleotides PAGE and UV melting analysis revealed that longer LNA-based splice-switching oligonucleotides (SSOs) formed secondary structures by themselves, reducing their effective concentration.
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