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Yuwenshu Zhou on Muck Rack

Yuwenshu Zhou

As seen in: Frontiers in Immunology
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Articles

From gut microbiota-driven mucosal barrier disruption to myeloid-dominant immunosuppressive niches in colorectal cancer

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By Na Lu, Lei Zhang, Hanyu Sun, Changrui Zhao, YUE WANG, Yuwenshu Zhou
| Frontiers in Immunology
Abstract Colorectal cancer (CRC) develops within a mucosal ecosystem in which epithelial barrier function, colonizing microbes, inflammatory signaling, and immune cell composition are closely interdependent. Immune checkpoint inhibitors have significantly altered treatment outcomes in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) CRC, but most microsatellite-stable (MSS) tumors still respond poorly, and this is not solely due to lower antigenicity.
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