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Yuyin Pan

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Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis - Nature Chemical Biology

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By Yuyin Pan, Junmei Lu, Xinran Feng, Pilong Li, Shouqing Luo
| Nature Verified
Abstract RNA molecules with the expanded CAG repeat (eCAGr) may undergo sol–gel phase transitions, but the functional impact of RNA gelation is completely unknown. Here, we demonstrate that the eCAGr RNA may form cytoplasmic gel-like foci that are rapidly degraded by lysosomes. These RNA foci may significantly reduce the global protein synthesis rate, possibly by sequestering the translation elongation factor eEF2.
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