Yuying Yang
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Plasma retinol binding protein 4 improves survival of Klebsiella pneumoniae-induced pneumosepsis through stimulation of neutrophils
Abstract A decrease in plasma retinol binding protein 4 (RBP4) was seen in sepsis patients. It is unknown whether the reduction is a specific indicator of sepsis or plays a role in sepsis pathogenesis. We addressed these questions using human cohorts consisting of 80 healthy, 68 non-sepsis infection (control for sepsis) and 471 sepsis subjects, and a mouse model of Klebsiella pneumoniae (KP)-induced pneumosepsis (KPS).
The SLC7A11–ferroptosis axis in BRCA1-mutant breast cancer: current mechanistic evidence, potential therapeutic vulnerabilities, and translational perspectives
Abstract BRCA1-mutant breast cancer is characterized by homologous recombination deficiency and genomic instability. Although these tumors are initially sensitive to platinum-based chemotherapy and PARP inhibitors, acquired treatment resistance remains a major clinical challenge. Ferroptosis is a potential therapeutic vulnerability, but the role of the SLC7A11/xCT–ferroptosis axis in this disease remains unclear.
Efficacy of supplementation with nutrients and dietary supplements on recovery and inflammatory response among patients with COVID-19: a network meta-analysis
Abstract Background: At present, the clinical course of COVID-19 is synergistically influenced by the systemic inflammatory storm and nutritional deterioration triggered by COVID-19. Nutrition interventions have demonstrated potential clinical value. Objective: This study aims to systematically compare the relative efficacy of different dietary patterns and nutritional supplements on key outcomes among adult patients with COVID-19, and to identify the optimal regimen of nutrition intervention.
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