Yuying Ye

Correction to: Nature Methods https://doi.org/10.1038/s41592-024-02553-7, published online 10 December 2024. In the original publication, two DIA datasets—the dose-response rapamycin dataset corresponding to Extended Fig. 1b, d and the dose-response HSP90 inhibitor dataset corresponding to Supplementary Fig. 21—were searched using Spectronaut version 18.1. All other DIA datasets were searched using Spectronaut version 15.3, as now clarified in the Methods “DIA spectra analysis” subsection.

Abstract : Although the use of detergents in thermal proteome profiling (TPP) has become a common practice to identify membrane protein targets in complex biological samples, surprisingly, there is no proteome-wide investigation into the impacts of detergent introduction on the target identification performance of TPP.