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Articles by Yvette A. Luyten
Proxi-RIMS-seq2 applied to native microbiomes uncovers hundreds of known and novel m5C methyltransferase specificities.
Abstract Methylation patterns in bacteria can be used to study Restriction-Modification (RM) or other defense systems with novel properties. While m4C and m6A methylation is well characterized mainly through PacBio sequencing, the landscape of m5C methylation is under-characterized. To bridge this gap, we performed RIMS-seq2 on microbiomes composed of resolved assemblies of distinct genomes through proximity ligation.
Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine
Loading metrics Open Access Peer-reviewed Research Article Iain A. Murray , Yvette A. Luyten, Alexey Fomenkov, Nan Dai, Ivan R. Corrêa Jr., William G. Farmerie, Tyson A. Clark, Jonas Korlach, Richard D. Morgan, Richard J. Roberts Iain A. Murray, Yvette A. Luyten, Alexey Fomenkov, Nan Dai, Ivan R. Corrêa Jr., William G. Farmerie, Tyson A. Clark, Jonas Korlach, Richard D. Morgan, Richard J.
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM
Highlights • How restriction systems bias activities toward self or non-self is poorly understood • A solution to this problem is to couple enzyme activity to DNA-bound oligomeric state • CryoEM structure of DrdV at different stages of assembly with bound DNA targets • Three DNA-bound enzyme molecules are required per single DNA cleavage event Summary Restriction enzymes that combine methylation and cleavage into a single assemblage and modify one DNA strand are capable of efficient...
Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities
The creation of restriction enzymes with programmable DNA-binding and -cleavage specificities has long been a goal of modern biology. The recently discovered Type IIL MmeI family of restriction-and-modification (RM) enzymes that possess a shared target recognition domain provides a framework for engineering such new specificities. However, a lack of structural information on Type IIL enzymes has limited the repertoire that can be rationally engineered.
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