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Zabrina C. Lang on Muck Rack

Zabrina C. Lang

As seen in: Nature, BioRxiv
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Articles

Functional implications of the conformational landscape of a multidrug transporter revealed by Zebrafish Abcb4 structures

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By Jingyu Zhan, Chao-Ming Hsieh, Lothar Esser, Zabrina C. Lang, Abraham J. Morton, Robert W. Robey, Fei Zhou, Suresh V. Ambudkar, Rick Huang, Michael Gottesman, Di Xia
| Nature Verified
Abstract The hallmark of multidrug resistance conferred by the human ABC transporter ABCB1 (hP-gp) is the recognition and efflux of a diverse range of drugs, though the precise mechanism of polyspecificity remains unresolved. In aquatic animals such as zebrafish, Abcb4, a functional homolog of hP-gp, plays a vital role in surviving environmental toxicants. Here, we show that DrAbcb4 exhibits comparable basal and drug-stimulated ATPase activity to hP-gp.
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Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4

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By Jingyu Zhan, Lothar Esser, Chao-Ming Hsieh, Zabrina C. Lang
| BioRxiv
Abstract The hallmark of multidrug resistance conferred by human ABC transporter ABCB1 (hP-gp) is the recognition and efflux of diverse range of drugs, though the precise mechanism of polyspecificity remains unresolved. In aquatic animals such as zebrafish, Abcb4, a functional homolog to hP-gp, plays a vital role in surviving environmental toxicants. Here, we show that Abcb4 exhibits comparable basal and drug-stimulated ATPase activity to hP-gp.
Open in Who Shared Issue with article?
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