After being drafted by the 49ers, Smith took the league by storm during his first two seasons, finishing second in the Defensive Rookie of the Year race before earning Pro Bowl and All-Pro honors in his second year. In that span, he posted a combined 33.5 sacks across 32 games with San Francisco. After four years with the 49ers, he played his only season with the then-Oakland Raiders in 2015 after the 49ers released him following a third DUI arrest.