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Zachary Barsdale on Muck Rack

Zachary Barsdale

As seen in: Nature
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Articles

AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing

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By Y. Tao, Holt A. Sakai, Allen Jiang, Nicholas A. Krasnow, Smriti Pandey, Nouraiz Ahmed, Ting-Wei Liao, Ana Cristian, Emily Zhang, Joy Xu, Mattijs Bulcaen, David R. Liu, Vasilii S. Vaganov, Brian Shim, Zachary Barsdale, Keyede Oye
| Nature Verified
Abstract Although protein engineering and laboratory evolution have been used to optimize prime editors, we show that previous changes that improve prime editor efficiency also compromise protein stability and expression level, limiting performance.
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