Zaffar Equbal on Muck Rack

Zaffar Equbal

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Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype - Nature Communications

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By Zaffar Equbal, Lihua Zhu, Michael Green
| Nature Verified
Abstract X chromosome inactivation (XCI) is induced by Xist long non-coding RNA and protein-coding genes. However, the role of small non-coding RNA function in XCI remains unidentified. Our genome-wide, loss-of-function CRISPR/Cas9 screen in female fibroblasts identified microRNAs (miRNAs) as regulators of XCI. A striking finding is the identification of miR106a among the top candidates from the screen.
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