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Zahala Bar-On on Muck Rack

Zahala Bar-On

As seen in: BioRxiv
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Articles

Limiting mitochondrial-derived ATP transfer to the cytosol enhances T-cell activation

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By Omri Yosef, Leonor Cohen-Daniel, Oded Shamriz, Zahala Bar-On
| BioRxiv
Abstract T cell activation demands robust ATP and NAD+ supply, which often outpaces oxidative phosphorylation (OXPHOS) capacity. To understand how T cells overcome this, we limited mitochondrial ATP transfer in T-cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mice. Unexpectedly, these naive T cells showed heightened activation, proliferation, increased IFNγ production and cytotoxicity.
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Limiting mitochondrial-derived ATP transfer to the cytosol enhances T-cell activation

|
By Omri Yosef, Leonor Cohen-Daniel, Oded Shamriz, Zahala Bar-On
| BioRxiv
Abstract T cells often encounter oxidative phosphorylation (OXPHOS) insufficiency upon activation, due to increased demands for ATP and NAD+ to fuel anabolic reactions. To explore how T cells overcome this insufficiency, we indirectly restricted OXPHOS by limiting mitochondrial ATP transfer to the cytosol using a T-cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mouse.
Open in Who Shared Issue with article?
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