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Zaiying Jiang on Muck Rack

Zaiying Jiang

As seen in: Nature
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Deep brain stimulation ameliorates social deficits from early-life pain by restoring excitatory/inhibitory balance in the anterior cingulate cortex

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By Tao Du, Dou Yang, Xiangyu Zhang, Yunjian Huang, Siyi Liu Verified, Shiyun Xu, He Zhang, Guang Lu, Hongwei Zhu, Xiangdong Wan, Zaiying Jiang
| Nature Verified
Abstract The neural mechanisms underlying how early-life pain leads to long-term impairments in adult social deficit remain largely elusive. Here, by establishing a juvenile inflammatory pain model in mice and employing a combination of neuromodulation techniques, we found that early-life pain experience induces a specific and enduring social deficit in adulthood. This deficit originates from a persistent excitatory/inhibitory (E/I) imbalance within the anterior cingulate cortex (ACC).
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